Prolotherapy OR Perineural Injection For Pain




Classical Prolotherapy was developed in the 1940s by American trauma surgeon Dr George Hackett. He introduced deep Glucose (Dextrose) injections in concentrations of up to 25% combined with local anaesthetics.

Who can benefit from Prolotherapy?

This has been proven to be an effective treatment for chronically painful conditions, attributed to ‘weak’ or ‘lax’ ligaments and tendons. Dr Hackett reasoned that ‘lax’ or ‘weak’ ligaments were the cause of most joint and ligament pain. He targeted lax or weak ligaments with high Glucose concentrations to stimulate inflammation. He proposed this inflammation would eventually lead to normal repair and make tendons and ligaments stronger. Strengthening these tendons and ligaments would resolve the pain. Dr Hackett was successful in treating chronic pain and published 16 articles and a textbook on this procedure. He claimed an 80% success rate for the treatment of conditions like chronic low back pain and many other painful conditions. A growing number of classical prolotherapy studies over the last 40 years have indicated very good to excellent results from high concentration Glucose (Dextrose) treatments of joints, ligaments and tendons.

Neural Prolotherapy is a distinct and separate treatment modality and has been developed by Dr John Lyftogt since 2002. Neural Prolotherapy was initially developed for the treatment of Achilles tendonitis and differs from Classical prolotherapy in that the injections are given immediately under the skin while taking great care avoiding needle contact with the exquisitely sensitive tendon. This ‘subcutaneous’ or ‘neural prolotherapy’ protocol was successfully extended to the treatment of tennis elbow, painful knees, shoulders, wrist, neck, hips, ankles, low back pain and compartment syndrome. Results are consistent and two year follow up studies have shown success rates between 80-90%.

Prolotherapy Edmonton – SMRT Health Centre – Perineural Injection

(780) 705 0450Book Now

14256 23 Avenue SW Edmonton, AB T6R 3B9

Perineural Injection Therapy aka Neural Prolotherapy



WHAT IS Perineural Injection Treatment (PIT) also known as Neural Prolotherapy?

Perineural Injection AKA Neural Prolotherapy for Pain Relief is an exciting, new, and highly effective form of pain treatment. It involves multiple small injections just beneath the skin along painful tender regions that correspond to small nerves. The technique was developed by Dr. John Lyftogt, a sports medicine doctor in New Zealand who has been treating patients with chronic pain since 1978. Less invasive than classical Prolotherapy, Perineural Injection Therapy consistently sees success rates of up to 80-100%.

Who can benefit from Perineural Injection?

Anyone with pain, chronic or otherwise: Individuals who have been treated in the past with multiple surgeries and cortisone injections that have nonetheless remained in pain have seen their pain disappear with a few Neural Prolotherapy treatments.

Neural Prolotherapy effectively treats fibromyalgia, headaches, tennis elbow, painful knees, shoulder pain, neck, hip, and rib pain, muscle injuries, low back pain, foot pain- Morton’s Neuroma, Achilles – and more! Generally, tendinitis, arthritis, bursitis, sciatica and muscle/ligament injuries are targeted.

What is injected?

A 5% dextrose solution in sterile water, it is safe and relatively harmless.

What are the risks or side effects of Perineural Injection?

Bruising and soreness at the injection site are sometimes experienced but are not common. As with any injection there is a risk of infection or an allergic reaction however these are uncommon. No allergic reactions have yet been observed.

How does Perineural Injection Work?

The nerve that innervates a joint also innervates the skin overlying that joint and muscles that move the joint. Dr. Lyftogt discovered that inflamed nerves that supplies sensation to the skin over a joint also cause pain to the muscles and tissue around that joint. He found that restoration of those small nerves functions will lead to healing in deeper structures and reduction in pain.

The working hypothesis is that dextrose solution promotes healing of the connective tissues such as ligaments, tendons and inflamed nerves. These inflamed nerves under the skin are known to cause chronic painful conditions called “neuralgias